SCS-C000534

eurotiumide A

Pathway: Shikimates and Phenylpropanoids Superclass: Coumarins Class: Isocoumarins

Chemical Structure

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Source Information

Eurotium sp. (gorgonian-derived fungus)

Kingdom Fungi Phylum Ascomycota Class Eurotiomycetes Order Eurotiales Family Aspergillaceae Genus Eurotium Species NA

South China Sea

DOI: 10.1016/j.tet.2014.08.055 · Tetrahedron

Drug-likeness (Lipinski Ro5)

Molecular Weight

348.4 Da

Threshold ≤ 500

ALogP

4.41

Threshold ≤ 5

H-Bond Donors

Threshold ≤ 5

H-Bond Acceptors

Threshold ≤ 10

Passes Lipinski Rule of Five — drug-like candidate

Chemical Properties

Molecular Formula:

C20H28O5

Molecular Weight:

348.4000 Da

SMILES:

CCCCC[C@@H]1OC(=O)c2c(O)c(CC=C(C)C)cc(O)c2[C@H]1OC

InChIKey:

                        SOCRUGYUGDSRET-KXBFYZLASA-N
                        
                    

InChI:

InChI=1S/C20H28O5/c1-5-6-7-8-15-19(24-4)16-14(21)11-13(10-9-12(2)3)18(22)17(16)20(23)25-15/h9,11,15,19,21-22H,5-8,10H2,1-4H3/t15-,19-/m0/s1

Calculated Properties

ALogP:

4.413 lipophilicity

TPSA:

75.99 Å² polar surface area

H-Bond Donors:

H-Bond Acceptors:

Rotatable Bonds:

Ring Count:

2 (1 aromatic)

Chiral Centers:

Fsp³:

0.5500 fraction sp³ carbon

Database Information

Compound ID:

SCS-C000534

NPClassifier Pathway:

Shikimates and Phenylpropanoids

NPClassifier Superclass:

Coumarins

NPClassifier Class:

Isocoumarins

Glycoside:

NPClassifier Status:

Classified

External Links:

General chemistry

PubChem ChemSpider ChEMBL

Natural product databases

COCONUT NP Atlas

Biological Activity Data

Activity values are displayed only when a quantitative or clearly reported result is available. Tested organisms, cell lines and molecular targets are shown under Target / model.

Activity	Assay	Target / model	Result	Reference
Antibacterial	—	potent activity	— Structured numeric value is not available in this record; see the primary reference.	10.1016/j.tet.2014.08.055 Tetrahedron

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