SCS-C002002
porric acid D
Pathway: Polyketides
Superclass: Aromatic polyketides
Class: Usnic acid and derivatives
Chemical Structure
Loading 3D structure...
3D conformers are computationally generated from SMILES by RDKit for visualization and download; they are not experimental crystal or NMR structures.
Source Information
Talaromyces mangshanicus
(NA)
Kingdom
Fungi
Phylum
Ascomycota
Class
Eurotiomycetes
Order
Eurotiales
Family
Trichocomaceae
Genus
Talaromyces
Species
Talaromyces mangshanicus
South China Sea
DOI:
10.27493/d.cnki.gzdzy.2019.000726
· CNKI Dissertation
Drug-likeness (Lipinski Ro5)
Molecular Weight
288.2 Da
Threshold ≤ 500
ALogP
3.01
Threshold ≤ 5
H-Bond Donors
3
Threshold ≤ 5
H-Bond Acceptors
5
Threshold ≤ 10
Passes Lipinski Rule of Five — drug-like candidate
Chemical Properties
Molecular Formula:
C15H12O6
Molecular Weight:
288.2500 Da
SMILES:
COc1cc(C(=O)O)c2oc3c(O)c(O)cc(C)c3c2c1
InChIKey:
ZCQTZTJLYWJXFU-UHFFFAOYSA-N
InChI:
InChI=1S/C15H12O6/c1-6-3-10(16)12(17)14-11(6)8-4-7(20-2)5-9(15(18)19)13(8)21-14/h3-5,16-17H,1-2H3,(H,18,19)
Calculated Properties
ALogP:
3.012 lipophilicity
TPSA:
100.13 Ų polar surface area
H-Bond Donors:
3
H-Bond Acceptors:
5
Rotatable Bonds:
2
Ring Count:
3
(3 aromatic)
Chiral Centers:
0
Fsp³:
0.1333 fraction sp³ carbon
Database Information
Compound ID:
SCS-C002002
NPClassifier Pathway:
Polyketides
NPClassifier Superclass:
Aromatic polyketides
NPClassifier Class:
Usnic acid and derivatives
Glycoside:
No
NPClassifier Status:
Classified
External Links:
General chemistry
Natural product databases
Biological Activity Data
Activity values are displayed only when a quantitative or clearly reported result is available.
Tested organisms, cell lines and molecular targets are shown under Target / model.
| Activity | Assay | Target / model | Result | Reference |
|---|---|---|---|---|
| Antibacterial | MIC | Staphylococcus aureus (SA) | MIC (SA) >100 | 10.27493/d.cnki.gzdzy.2019.000726 CNKI Dissertation |
| Antibacterial | MIC | Methicillin-resistant S. aureus (MRSA) | MIC (MRSA) = 12.5 | 10.27493/d.cnki.gzdzy.2019.000726 CNKI Dissertation |
| Antifungal | MIC | Candida albicans SC5314 | MIC (C. albicans SC5314) = 100 | 10.27493/d.cnki.gzdzy.2019.000726 CNKI Dissertation |
| Antifungal | MIC | Candida albicans 17# | MIC (C. albicans 17#) >100 | 10.27493/d.cnki.gzdzy.2019.000726 CNKI Dissertation |
| Antifungal | MIC | Candida albicans G5 | MIC (C. albicans G5) = 100 | 10.27493/d.cnki.gzdzy.2019.000726 CNKI Dissertation |
| Antimycobacterial | MIC | Mycobacterium bovis BCG | MIC (BCG) = 50 (unit: ug/mL) | 10.27493/d.cnki.gzdzy.2019.000726 CNKI Dissertation |