SCS-C006233

violapyrone C

Pathway: Polyketides Superclass: Cyclic polyketides Class: 2-pyrone derivatives

Chemical Structure

Loading 3D structure...

3D conformers are computationally generated from SMILES by RDKit for visualization and download; they are not experimental crystal or NMR structures.

Download: SDF SMILES

Source Information

Streptomyces somaliensis SCSIO ZH66 (NA)

Kingdom Bacillati Phylum Actinomycetota Class Actinomycetes Order Kitasatosporales Family Streptomycetaceae Genus Streptomyces Species Streptomyces somaliensis

South China Sea · 3536 meters · 120° 0.250′E; 20° 22.971′N

DOI: 10.1186/s12934-016-0515-6 · Microbial Cell Factories

Drug-likeness (Lipinski Ro5)

Molecular Weight

238.3 Da

Threshold ≤ 500

ALogP

3.41

Threshold ≤ 5

H-Bond Donors

Threshold ≤ 5

H-Bond Acceptors

Threshold ≤ 10

Passes Lipinski Rule of Five — drug-like candidate

Chemical Properties

Molecular Formula:

C14H22O3

Molecular Weight:

238.3270 Da

SMILES:

CC[C@H](C)CCCCc1cc(O)c(C)c(=O)o1

InChIKey:

                        CWVDWOPGUAUQDD-JTQLQIEISA-N
                        
                    

InChI:

InChI=1S/C14H22O3/c1-4-10(2)7-5-6-8-12-9-13(15)11(3)14(16)17-12/h9-10,15H,4-8H2,1-3H3/t10-/m0/s1

Calculated Properties

ALogP:

3.413 lipophilicity

TPSA:

50.44 Å² polar surface area

H-Bond Donors:

H-Bond Acceptors:

Rotatable Bonds:

Ring Count:

1 (1 aromatic)

Chiral Centers:

Fsp³:

0.6429 fraction sp³ carbon

Database Information

Compound ID:

SCS-C006233

NPClassifier Pathway:

Polyketides

NPClassifier Superclass:

Cyclic polyketides

NPClassifier Class:

2-pyrone derivatives

Glycoside:

NPClassifier Status:

Classified

External Links:

General chemistry

PubChem ChemSpider ChEMBL

Natural product databases

COCONUT NP Atlas

Biological Activity Data

Activity values are displayed only when a quantitative or clearly reported result is available. Tested organisms, cell lines and molecular targets are shown under Target / model.

Activity	Assay	Target / model	Result	Reference
Antibacterial	MIC	methicillin-resistant Staphylococcus aureus (MRSA)	two (4 and 5) exhibited improved anti-MRSA activity than VLP B; all of them with the exception of 2 showed inhibition against MRSA at the concentration of 100 μg/well	10.1186/s12934-016-0515-6 Microbial Cell Factories

Back to Compounds