SCS-C006242

tanzawaic acid Z1

Pathway: Polyketides Superclass: Cyclic polyketides Class: Decalins with side chains

Chemical Structure

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Source Information

Penicillium steckii (Penicillium)

Original source name: Penicillium steckii | Penicillium stecki

Kingdom Fungi Phylum Ascomycota Class Eurotiomycetes Order Eurotiales Family Aspergillaceae Genus Penicillium Species Penicillium steckii

South China Sea

DOI: 10.3390/md24050147 · Marine Drugs

Drug-likeness (Lipinski Ro5)

Molecular Weight

306.4 Da

Threshold ≤ 500

ALogP

2.53

Threshold ≤ 5

H-Bond Donors

Threshold ≤ 5

H-Bond Acceptors

Threshold ≤ 10

Passes Lipinski Rule of Five — drug-like candidate

Chemical Properties

Molecular Formula:

C18H26O4

Molecular Weight:

306.4020 Da

SMILES:

CC1=C[C@H](O)[C@H]2C[C@@](C)(O)C[C@@H](C)[C@H]2[C@@H]1/C=C/C=C/C(=O)O

InChIKey:

                        DLWBFBILYYRXDQ-LZQUJLCYSA-N
                        
                    

InChI:

InChI=1S/C18H26O4/c1-11-8-15(19)14-10-18(3,22)9-12(2)17(14)13(11)6-4-5-7-16(20)21/h4-8,12-15,17,19,22H,9-10H2,1-3H3,(H,20,21)/b6-4+,7-5+/t12-,13-,14-,15+,17+,18+/m1/s1

Calculated Properties

ALogP:

2.534 lipophilicity

TPSA:

77.76 Å² polar surface area

H-Bond Donors:

H-Bond Acceptors:

Rotatable Bonds:

Ring Count:

2 (0 aromatic)

Chiral Centers:

Fsp³:

0.6111 fraction sp³ carbon

Database Information

Compound ID:

SCS-C006242

NPClassifier Pathway:

Polyketides

NPClassifier Superclass:

Cyclic polyketides

NPClassifier Class:

Decalins with side chains

Glycoside:

NPClassifier Status:

Classified

External Links:

General chemistry

PubChem ChemSpider ChEMBL

Natural product databases

COCONUT NP Atlas

Biological Activity Data

Activity values are displayed only when a quantitative or clearly reported result is available. Tested organisms, cell lines and molecular targets are shown under Target / model.

Activity	Assay	Target / model	Result	Reference
Antitumor	cell viability	Caco-2 cells	> 90.0 %	10.3390/md24050147 Marine Drugs

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